The prize has been awarded for efforts made by cse in fighting powerful, topdown bureaucratic resource. These axons are distributed in an organized pattern from the soma of the rgc to the lateral geniculated nucleus where most of the neurons synapse. Designed as both a learning tool for students and a reference for clinicians to use when faced with a challenging topography interpretation, atlas and clinical reference guide for corneal topography will be appreciated by a wide spectrum of eye care professionals. It reaches both retinal specialists and general ophthalmologists with practical insight. Figueredo is a story about a young baseball player named rudy. Domainspecific issues sparse convnets compressed sensing feature. King the divinity school, harvard university, cambridge, ma 028 email.
Optic nerve head analysis report adapted from carl zeiss oct manual. With its high resolution and proven measurement reproducibility. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using octa can promote better use of nonhuman primate. The texts primary objective is to illustrate the appearance of the eye in health and disease, comparing conventional clinical technologies using spectral domain oct imaging.
Influence of axial length on peripapillary retinal nerve fiber layer thickness in children. The cornea is the most external layer of the eye and serves two important roles in 1 the refraction of light and 2 protection from the outside environment, both of which are highly dependent on the collagen assembly of the corneal stroma. Optical coherence tomography of ocular diseases, third edition is written with the clinician in mind. This is an open access article published by world scientific publishing company.
In followups, progression analysis by rtvue compares the rnfl thickness measurements and the gcc map over time and thus, determines whether statistically. Identification of structural damage to the optic nerve and retinal nerve fiber layer rnfl is an essential component of diagnosis and management of glaucoma. Coauthor of the first oct clinic paper and book, mit. Oct 27, 2016 recipes and stories from a modern diner. Optical coherence tomography oct is a noninvasive imaging technique. Huang has coauthored several books on anterior segment oct, including anterior segment optical coherence tomography and imaging the eye from front to back with rtvue fourierdomain optical coherence tomography. Viewers are given an overview of scanning protocols on various sdoct systems as lecturers present an organized method for analysis of images and identification of pathology. Ophthalmic imaging is an integral part of the work of all ophthalmic departments.
Glaucoma is obviously an important part of this book, but one part is. This study sought to determine the collagen fiber arrangement of the canine corneal stroma and correlate the stromal organization with tissue stiffness. Shallow introduction for deep learning retinal image analysis 1. Optical coherence tomography oct is a useful adjunct imaging technique for retinal and optic nerve pathology. It thus provides a flow map with depthresolved visualization of the various vascular layers in the posterior pole of the eye including the retina capillary plexus and the choroid. He authored more than 190 research publications and edited 17 books on inherited and environmentally induced retinal degenerations. Sergott editor this richly illustrated, comprehensive guide will enable the reader to identify anatomy and ophthalmic disease as illustrated on optical coherence tomography oct. Detailed information on the oct imaging and interpretation is provided for the evaluation of disease progression in numerous neurodegenerative. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Further distribution of this work is permitted, provided the original work is properly cited. Zeiss have agreed to write, publish and distribute this book free of charge. Cynomolgus macaques is widely used in ophthalmic disease research. Several studies have been published evaluating the accuracy of different structural measurements obtained with sdoct for diagnosing glaucoma 1923. Comparison of zeiss cirrus and optovue rtvue oct angiography systems.
Atlas and clinical reference guide for corneal topography. There are normals for ocular structures deviation from the norm abnormality pathology being able to discern differences in reflectivity, morphology and qualitative measures either from normals or from previous scans is the essence of oct interpretation. Making the most of anterior segment oct the detailed images produced by this technology are proving to be of value in many clinical situations. Guide to interpreting spectral domain oct by patty seiden. The authors suggested that the rtvue oct appeared to report more accurate, but thinner cct. At present, level 1 evidence of the technologys clinical applications doesnt exist. Optical coherence tomography for glaucoma diagnosis. Interpretation of oct american academy of ophthalmology. Retinal thickness in black and indian myopic students at. Macular thickness maps may also be helpful in making the diagnosis of nonglaucomatous optic neuropathies. This monograph aims to give an update on the use of oct in glaucoma and pathologies of the optic nerve. The optic nerve on is constituted by the axons of the retinal ganglion cells rgcs. Detection of disease progression is an important and challenging component of glaucoma management. Home ophthalmology books oct in central nervous system diseases.
Request pdf on jan 1, 2015, david huang and others published chapter02 interpretation of optical coherence tomography angiography find, read and cite all the research you need on researchgate. Therapeutic and surgical treatment of the posterior segment delivers indepth coverage of the latest advances in amd, diabetic retinopathy, macular edema, retinal vein occlusion as well as surgical intervention in posterior segment care. Glaucoma is obviously an important part of this book, but one part is devoted to other eye diseases and especially. The metabolic activity of retina is higher than other human tissues and is crucial to the vision. To make a correct interpretation of oct measurements, ocular magnification effect should be taken into account by clinicians or oct manufacturers. Provides key feature points for each disorder giving you the needtoknow oct essentials for quick comprehension and rapid reference.
The preliminary statistical analysis revealed that macular retinal thickness measurements of the right and left eyes showed significantly high levels of symmetry. Figure 1 shows a cross sectional bscan from the rtvue in the macula region. An excellent diagnostic companion tohandbook of retinal oct. The first chapter covers the basic principles and interpretation of oct and is intended to help the reader interpret oct images. It allows the clinician to record the findings from clinical ocular examination in an objective, reproducible, transmissible and durable manner. The main objective of this investigation was to compare. Participants ages ranged from 18 to 24 years with the mean age of the black and indian participants being 21.
Introduction to optical coherence tomography request pdf. Oct is a well known and frequently used technology to image the posterior segment. Optical coherence tomography has become a powerful tool for analyzing the retina and other ocular structures. Pearls and pitfalls of optical coherence tomography. Summarize research about oct related to diagnosis and progression 4. Guide to interpreting spectral domain oct a stepbystep guide for interpreting images and data using cirrus hdoct. Repeatability of cornea and sublayer thickness measurements. The russian soldier came out of the building on the edge of the baseball field, holding a ball on his hand. Analysis of current literature regarding oct in diagnosis and management of vitreomacular interface disease. The mean frequency of correct identification of the 26 lesions was 70% standard deviation sd 15% before instruction. Several studies have been published evaluating the accuracy of different structural measurements obtained with sd oct for diagnosing glaucoma 1923. Spectraldomain optical coherence tomography for glaucoma. Twentysix blackandwhite hr oct images were projected, and clinicians were asked to determine whether the lesions represented ocular surface squamous neoplasia ossn or another ocular surface pathology.
Files of the type oct or files with the file extension. Glaucoma is a multifactorial optic neuropathy characterized by a loss. Metaanalysis was performed pooling area under the receiver operating characteristic curve auroc estimates for all devices, stratified by oct type rnfl. Optical coherence tomography spectral domain oct interpretation case series. The key points of the on are the optic nerve head and chiasm. It reaches both retinal specialists and general ophthalmologists with practical insight regarding current and future treatment strategies. Nov 26, 2018 ophthalmic surgery, lasers and imaging retina. This combination has enabled us to bring a fresh perspective to oct, and to create the most innovative, versatile technology available today.
Manger iii, md chair of corneal laser surgery assoc. Oct angiogram fields of view and segmentation layers on angiovue. The normal left eye of a 56 year old caucasian man using the angiovue optical coherence tomography angiography octa software of the rtvue xr avanti optovue, inc. When he noticed that rudy was holding a bat, he came toward. Aug 20, 2016 shallow introduction for deep learning retinal image analysis 1. Viewers are given an overview of scanning protocols on various sd oct systems as lecturers present an organized method for analysis of images and identification of pathology. A total of 109 eyes from 59 subjects were scanned with two sdoct devices cirrus and rtvue at the same visit. The rtvue oct can be helpful to detect glaucomatous damage by quantifying the rnfl thickness, the layers associated with the ganglion cells i. Review strengths and weaknesses of oct for glaucoma 3.
Oct technology generates highresolution, crosssectional and threedimensional 3d images of the retina, optic disc and anterior segment, to give you valuable information that aids in the diagnosis and management of a range of ocular diseases. This is part of the spectral domain oct interpretation for the general ophthalmologist series, which focuses on use of sdoct in patients with glaucoma and retinal disease. Reproducibility of central corneal thickness measurements. Posterior vitreous detachment is typically a nonpathologic agerelated event. Jan 04, 2018 early detection, monitoring and understanding of changes in the retina are central to the diagnosis of glaucomatous optic neuropathy, and vital to reduce visual loss from this progressive condition. Apr 12, 2011 making the most of anterior segment oct the detailed images produced by this technology are proving to be of value in many clinical situations. Guide to interpreting spectral domain oct by patty seiden issuu. Provide tips for better oct analysis in clinical practice. The place of the gospel of philip in the context of early christian claims about jesuss marital status karen l. Optical coherence tomography angiography octa is a new, noninvasive imaging technique that generates volumetric angiography images in a matter of seconds. Ideal at any stage of your career, this easytouse, clinically oriented handbook provides a quick, templated, and portable guide for the interpretation of optical coherence tomography scans.
Ability of novice clinicians to interpret highresolution. Novice clinicians were more accurate in correctly determining that a lesion was not an ossn ruling it out as a diagnosis than in determining that a lesion was an. Add it all up and you arrive at an unparalleled combination of ease and clinical utility that makes the iseries the best value in octwhich leads to optimum eye health for your patients. Optical coherence tomography oct has proved to be valuable in the detection of glaucomatous damage. Spectralis and cirrus highdefinition oct take the outer most layer, rpe while rtvue takes the inner. Visual field vf, spectralis rnfl 83 patients and 37 healthy subjects and rtvue rnfl data obtained separately 56. The second edition of oct and imaging in central nervous system diseases offers updated stateoftheart advances using optical coherence tomography oct regrading neuronal loss within the retina. Sep 10, 2019 optical coherence tomography oct is a noninvasive imaging technique. Sunita narain, noted environmental scientist and director of delhibased centre for science and environment cse, has been honoured with the 2005 stockholm water prize. The evaluation and comparison of macular and optic disc vascular circulation parameters between normal adult cynomolgus macaques and healthy adult humans using oct a can promote better use of nonhuman primate models in studies of. Comparison of zeiss cirrus and optovue rtvue oct angiography. Direct ganglion cell assessment with the rtvue 3 optovue oct. The rtvue has several unique features encompassing imaging and analysis and technological capability. A 20minute instructional lecture was given on hr oct interpretation, and the same 26 images were shown.
Advances in oct have made it a useful diagnostic tool in ethambutol toxicity, hydroxychloroquine retinopathy, optic nerve head drusen, glaucoma, idiopathic intracranial hypertension, and multiple sclerosis, to name a few conditions. When he noticed that rudy was holding a bat, he came toward rudy. Jun 10, 2010 guide to interpreting spectral domain oct a stepbystep guide for interpreting images and data using cirrus hd oct. Comparison of vascular parameters between normal cynomolgus. It is distributed under the terms of the creative commons attribution 4. The content of this book presents the viewpoint of the author and do not necessarily. The introduction of spectraldomain oct sd oct has allowed objective quantification of damage. Optical coherence tomography has emerged over the years with the ability to detect. The rtvue sdoct system was launched in 2006 with fast retina mapping. The use of spectral domain optical coherence tomography sd oct technology has enabled clinicians to obtain highresolution images of the optic nerve head onh, rnfl and macular regions. An understanding of the underlying principles for a specific imaging technology is essential for accurate data interpretation, especially since noncontact cct measurement devices are potentially more practical to employ in a busy clinical practice.
The use of spectral domain optical coherence tomography sdoct technology has enabled clinicians to obtain highresolution images of the optic nerve head onh, rnfl and macular regions. Heres a howto on differentiating oct models and reading their scans. Discuss glaucoma diagnosis and progression in terms of oct 2. Chapter02 interpretation of optical coherence tomography. Another advantage of the iseries systems is completeness, the capacity for one oct to deliver the full spectrum of applications from retina to cornea. Michael deiner 27 ucsf department of ophthalmology. Oct in glaucoma diagnosis, detection and screening intechopen. A pdf printer is a virtual printer which you can use like any other printer. This is a nascent technology with a potential wide applicability for retinal vascular disease. Optical coherence tomography angiography octa employs a novel imaging algorithm that detects the amplitude or phase decorrelation of blood cell movement. We also observed that sdoctderived measurements of cct tended to be thinner than with the schiempflug camera. This is part of the spectral domain oct interpretation for the general ophthalmologist series, which focuses on use of sd oct in patients with glaucoma and retinal disease.
Interpretation of the oct image and some new developments topics. Research article open access comparison of vascular parameters between normal cynomolgus macaques and healthy humans by optical coherence tomography angiography. A quantitative and qualitative approach examining the three. The first chapter concerns the principles and interpretation of oct and has a purely practical function, to help the reader understand the results. Environews, october 2005 3 news flash water prize for sunita m narain s. Oct in glaucoma and pathologies of the optic nerve. The authors suggested that the rtvue oct appeared to report more accurate, but thinner cct measurements, than the oculyzer 2. Shallow introduction for deep learning retinal image analysis. Reproducibility of central corneal thickness measurements in. The rtvue offers comprehensive glaucoma evaluation by providing assessment of the rnfl thickness, optic disc morphology, and the ganglion cell complex thickness. Anomalous posterior vitreous detachment emerges when the vitreous cortex fails to cleanly detach from the macula, optic nerve, or other adherent sites. To estimate the floor of retinal nerve fibre layer rnfl thickness measurements and the corresponding retinal sensitivity loss in glaucoma. The oct image 7 normal retina and key retinal pathologies. Sep 15, 2015 the anatomy of an oct scan octsand their printoutscan be tough to understand.
Oct interpretation jamin brown, md retina vitreous associates of cny december 6th 2014. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The broad spectrum of application of optical coherence. The avanti embodies many of the firsts in sdoct development that optovue has introduced to eye care. With handbook of retinal oct, you can master the latest imaging methods used to evaluate retinal disease, uveitis, and optic nerve disorders. Macular thickness analysis for glaucoma diagnosis and management. The vessel density vd was measured using an rtvue xr with angiovue.
Clinical use of oct in assessing glaucoma progression. Clinical experience with fourier domain oct retina today. Optovue oct has a broad range of applications in todays eye care practices. Guide to oct image interpretation with normal and anatomic. This open access book provides a comprehensive overview of the application of. The analysis report varies with different oct systems. Optical coherence tomography, by the same expert author team of drs. The module also offers angletoangle imaging for efficient anterior chamber angle evaluation. Role of optical coherence tomography in the evaluation and.
All three of these structures are affected in glaucoma. What you need to convert a oct file to a pdf file or how you can create a pdf version from your oct file. Rnfl parameters of the rtvue100 oct have shown high specificity 12. No part of this book may be reproduced or transmitted in any form or by any means. Detailed information on the oct imaging and interpretation is provided for.
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